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KMID : 0354419770050020045
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Medical Postgraduate
1977 Volume.5 No. 2 p.45 ~ p.50
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Effect of Postural Change on Urinary Aldosterone Excretetion During Furosemide Diuresis in Normal Subjects
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성호경/Sung, H.K.
고주환/이장규/박기복/이경희/장호조/서성희/Ko, Jr./Lee, J.K./Park, K./Lee, K.H./Chang, H.J./Suh, S.H.
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Abstract
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Postural difference of urinary aldosterone concentration during furocemide diuresis was observed in 10 normotensive young male volunteers.
Subjects were on normal Korean foods containing high sodium through the experiment. Forty miligrams of furosemide was parenterally administerde at two hours after 500ml water load. Urine specimen were collected at 30, 60, 90 and 120 minutes after the administration in the supine or standing postures. Urinary sodium and potassium concentrations were measured by flame photometry, and aldosterone concentration was determined by radioimmunoassay.
Results were as follows :
1. Total diuretic effect of furosemide decreased on standing, which showed initial decrease and subsequent increase.
2. Standing posture resulted in an increase in urinary aldosterone concentration and wider postural differences were noted after the furosemide administration.
3. Urinary sodium concentration showed a lower value in standing as to compare with the supine.
4. Urinary ratio of potassium to sodium increased in course of time after the diuretics especially in standing posture.
5. The relation of postural differences of urinary aldosterone and K/Na ratio following furosemide administration was discussed.
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